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Affiliation |
IWATE University Faculty of Science and Engineering Department of Science and Engineering Materials Science Course |
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Position |
Associate Professor |
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Laboratory Address |
〒0208551 4-3-5, Ueda, Morioka |
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Laboratory Phone number |
+81-19-621-6311 |
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Mail Address |
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SHIBA Yoko
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Research Interests 【 display / non-display 】
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ArfGAPs
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membrane traffic
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Extracellular vesicles
Graduating School 【 display / non-display 】
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-1111.11
University of Tsukuba Second Cluster of College Graduated
Graduate School 【 display / non-display 】
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-1111.11
University of Tsukuba Doctor's Course Completed
Degree 【 display / non-display 】
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University of Tsukuba - Doctor of Philosophy in Science 2004.03.25
Campus Career 【 display / non-display 】
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2016.05-Now
IWATE University Faculty of Science and Engineering Department of Chemistry and Biological Science Studies in Biological Sciences Associate Professor [Duty]
Course Subject 【 display / non-display 】
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2023
Molecular Cell Biology 3
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2023
Biochemistry
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2020
Introduction to project-based learning
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2020
Graduation Research
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2020
English for Science 1
Published Papers 【 display / non-display 】
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Magnetic control of membrane damage in early endosomes using internalized magnetic nanoparticles
Yuta Yonekawa, Kazuki Oikawa, Boldbaatar Bayarkhuu, Kizuna Kobayashi, Nana Saito, Ibuki Oikawa, Ryohei Yamada, Yu-han Chen, Koichi Oyanagi, Yuji Shibasaki, Satoru Kobayashi, Yoko Shiba
Cell Structure and Function 50 ( 1 ) 25 - 39 2025.02 [Refereed]
Academic Journal Multiple authorship
磁性ナノ粒子を乳がんの細胞に取り込ませ、磁場を外部から印加して初期エンドソームが特異的に損傷するか調べた論文。リソソームには膜損傷が起きず、初期エンドソーム特異的に損傷できることが明らかにした。
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ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation
Subhajit Poddar , Samuel D. Chauvin , Christopher H. Archer , Wei Qian , Jean A. Castillo-Badillo, Xin Yin , W. Miguel Disbennett , Cathrine A. Miner , Joe A. Holley , Teresa V. Naismith , W. Alexander Stinson , Xiaochao Wei , Yue Ning, Jiayuan Fu , Trini A. Ochoa , Nehalee Surve , Shivam A. Zaver , Kimberly A. Wodzanowski, Katherine R. Balka, Rajan Venkatraman, Canyu Liu, Kelly Rome, Will Bailis, Yoko Shiba, Sara Cherry , Sunny Shin, Clay F. Semenkovich, Dominic De Nardo, Sunnie Yoh , Elisha D.O. Roberson, Sumit K. Chanda, David J. Kast, Jonathan J. Miner
Cell S0092-8674 ( 25 ) 00096 2025.02 [Refereed]
Academic Journal Multiple authorship
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Arf GTPase-activating proteins ADAP1 and ARAP1 regulate incorporation of CD63 in multivesicular bodies
Kasumi Suzuki, Yoshitaka Okawa, Sharmin Akter, Haruki Ito and Yoko Shiba
Biology Open 2024.04 [Refereed]
Academic Journal Multiple authorship
4開膜貫通タンパク質CD63はクラスリンアダプターAP-3に結合するが、エクソソームの積荷でもある。エクソソームは多胞体(MVB)が細胞膜と融合し内腔小胞(ILV)が輸送されたものと考えられる。CD63のMVBへの輸送に関与するArfGAPをスクリーニングしたところ、ADAP1とARAP1が見つかった。ADAP１とARAP1の欠損細胞ではMVBへ輸送されるEGFRの輸送には影響がなかったため、EGFRとCD63は異なるMVBに輸送され、ADAP1とARAP1はCD63の輸送にのみ関与することが明らかとなった。
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Fabrication of hyperbranched-polyglycidol-Fe3O4 nanocomposite labeled with fluorescein isothiocyanate via rapid ligand exchange reaction
Ayane Kawamura, Mirai Saijyo, Boldbaatar Bayarkhuu, Naoki Nishidate, Ibuki Oikawa, Satoru Kobayashi, Koichi Oyanagi, Yoko Shiba, Tadashi Tsukamoto, Yoshiyuki Oishi , Yuji Shibasaki
Polymer 2024.01 [Refereed]
Academic Journal Multiple authorship
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Arf GTPase-Activating proteins SMAP1 and AGFG2 regulate the size of Weibel-Palade bodies and exocytosis of von Willebrand factor
Asano Watanabe, Hikari Hataida, Naoya Inoue, Kosuke Kamon, Keigo Baba, Kuniaki Sasaki, Rika Kimura, Honoka Sasaki, Yuka Eura, Wei-Fen Ni, Yuji Shibasaki, Satoshi Waguri, Koichi Kokame and Yoko Shiba
Biology Open ( The company of Biologists ) 2021.09 [Refereed]
Bulletin of University, Institute, etc. Multiple authorship
止血因子vWFはクラスリンアダプターAP-1の欠損によって分泌顆粒」WPBへの輸送が阻害されることが知られる。vWFのWPBへの輸送に関与するArfGAPをスクリーニングしたところ、SMAP1とAGFG2が見つかった。SMAP1欠損ではWPBが粒状になるが、AGFG２欠損では逆にWPBが長くなり、vWFの分泌が阻害されることがわかった。
Books 【 display / non-display 】
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ER stress, secretory granule biogenesis and insulin
Michiko Saito and Yoko Shiba
IntechOpen 2018.11 ISBN: 978-1-78984-922-6
Scholarly Book
Presentations 【 display / non-display 】
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ArfGAPs regulate the formation of secretory granules of von Willebrand factor,
Poster (General) Hataida H, Watanabe A, Sasaki K. and Shiba Y
2019.07-2019.08 -
ArfGAPs regulate the formation of secretory granules of von Willebrand factor
Poster (General) Hataida H, Watanabe A, Sasaki K. and Shiba Y
2019.06 -
ArfGAPs regulate the formation of secretory granules of von Willebrand factor,
Poster (General) Hataida H, Watanabe A, Sasaki K. and Shiba Y
2019.06 -
Do ArfGAPs perform shipping inspection? -The novel role of small G proteins-
Oral Presentation(Guest/Special) Yoko Shiba
2019.03 -
Do ArfGAPs perform shipping inspection? -The novel role of small G proteins-
Oral Presentation(Guest/Special) Yoko Shiba
2019.03
Association Memberships 【 display / non-display 】
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2015.04
Japanese Society for Cell Biology
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2018.11
Japanese Society on Thrombosis and Hemostasis
Academic Activity 【 display / non-display 】
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2024.04-2026.03
Japanese Society for Cell Biology