Tomokazu Fukuda

写真a

Affiliation

IWATE University  Faculty of Science and Engineering  Department of Chemistry and Biological Science  Studies in Biological Sciences 

Position

Professor
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Research Interests 【 display / non-display 】

  • Immortalized Cell

  • Critically Endangered Species

  • Radioactive Safety Evaluation

  • Carcinogenesis

  • Livestock Science

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Graduating School 【 display / non-display 】

  • 　
    -
    1999.03

    Kobe University   Faculty of Agriculture   Graduated

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Graduate School 【 display / non-display 】

  • 　
    -
    1999.03

    Nara Medical University  Graduate School, Division of Medicine  Doctor's Course  Completed

  • 　
    -
    1993.03

    Kobe University  Graduate School, Division of National Science and Technology  Master's Course  Completed

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Degree 【 display / non-display 】

  • Nara Medical University -  Ph.D.  1999.03.31

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Campus Career 【 display / non-display 】

  • 2017.05
    -
    Now

    IWATE University   Faculty of Agriculture   Food Animal Medicine & Food Safety Research Center   Professor   [Concurrently]

  • 2016.04
    -
    Now

    IWATE University   Faculty of Agriculture   Veterinary Medicine   Professor   [Concurrently]

  • 2016.04
    -
    Now

    IWATE University   Faculty of Science and Engineering   Department of Chemistry and Biological Science   Studies in Biological Sciences   Professor   [Duty]

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External Career 【 display / non-display 】

  • 2008.04
    -
    2016.03

    Tohoku University   Associate Professor  

  • 2005.05
    -
    2008.03

    National Cancer Center Research Institute of Japan   Technical Support Staff  

  • 2001.02
    -
    2005.04

    National Institute of Environmental Health Sciences, NIEHS-NIH   Visiting Fellow  

  • 1999.04
    -
    2001.01

    Japanese Foundation of Cancer Research   Technical Support Staff  

  • 1993.04
    -
    1995.03

    生物環境科学研究所   Staff Scientist  

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Research Areas 【 display / non-display 】

  • Life Science / Animal production science

  • Life Science / Pathological biochemistry

  • Environmental Science/Agriculture Science / Conservation of biological resources

  • Environmental Science/Agriculture Science / Radiation influence

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Recommended URL 【 display / non-display 】

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Course Subject 【 display / non-display 】

  • 2020

    Probability and Statistics

  • 2020

    Human Anatomy

  • 2020

    Biological Science and Engineering Laboratory 2

  • 2020

    Biological Science and Engineering Laboratory 1

  • 2020

    Reading Academic Papers in English 1

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Published Papers 【 display / non-display 】

  • Properties of a Single Amino Acid Residue in the Third Transmembrane Domain Determine the Kinetics of Ambient Light-Sensitive Channelrhodopsin

    Hatakeyama A, Sugano E, Sayama T, Watanabe Y, Suzuki T, Tabata K, Endo Y, Sakajiri T, Fukuda T, Ozaki T, Tomita H

    International Journal of Molecular Science   24 ( 5 ) 5054   2023.03  [Refereed]

    Bulletin of University, Institute, etc.  Single Work

    DOI PubMed

  • Comprehensive transcriptome data to identify downstream genes of testosterone signalling in dermal papilla cells

    Matsusaka H, Wu T, Furuya K, Yamada-Kato T, Bai L, Tomita H, Sugano E, Ozaki T, Kiyono T, Okunishi I, Fukuda T

    Scientific Data ( Nature Springer )  9   731   2022.11  [Refereed]

    Bulletin of University, Institute, etc.  Multiple authorship

    Testosterone-related steroid hormones are associated with various types of diseases, including prostate cancer and androgenetic alopecia (AGA). The testosterone or dihydroxy testosterone (DHT) circulates through the blood, binds to the androgen receptor (AR) in the cytoplasm, and finally enters the nucleus to activate downstream target genes. We previously found that immortalized dermal papilla cells (DPCs) lost AR expression, which may be explained by the repeated cell passages of DPCs. To compensate for the AR expression, DPCs that express AR exogenously were established. In this study, we performed an RNA-Seq analysis of the AR-expressing and non-AR-expressing DPCs in the presence or absence of DHT to identify the downstream target genes regulated by AR signalling. Furthermore, we treated DPCs with minoxidil sulphate, which has the potential to treat AGA. This is the first comprehensive analysis to identify the downstream genes involved in testosterone signalling in DPCs. Our manuscript provides high-priority data for the discovery of molecular targets for prostate cancer and AGA.

    DOI PubMed

  • Induced pluripotent stem cells of endangered avian species

    Katayama M, Fukuda T, Kaneko T, Nakagawa Y, Tajima A, Naito M, Ohmaki H, Endo D, Asano M, Nagamine T, Nakaya Y, Saito K, Watanabe Y, Tani T, Inoue-Murayama M, Nakajima N, Onuma M

    Communications biology ( Nature Publishing )  5   1049 - 1059   2022.10  [Refereed]

    Bulletin of University, Institute, etc.  Multiple authorship

    The number of endangered avian-related species increase in Japan recently. The applicationof new technologies, such as induced pluripotent stem cells (iPSCs), may contribute to therecovery of the decreasing numbers of endangered animals and conservation of geneticresources. We established novel iPSCs from three endangered avian species (Okinawa rail,Japanese ptarmigan, and Blakiston’sfish owl) with seven reprogramming factors (M3O,Sox2,Klf4,c-Myc,Nanog,Lin28, andKlf2). The iPSCs are pluripotency markers and expresspluripotency-related genes and differentiated into three germ layers in vivo and in vitro.These three endangered avian iPSCs displayed different cellular characteristics even thoughthe same reprogramming factors use. Japanese ptarmigan-derived iPSCs have differentbiological characteristics from those observed in other avian-derived iPSCs. Japanese ptar-migan iPSCs contributed to chimeras part in chicken embryos. To the best of our knowledge,ourfindings provide thefirst evidence of the potential value of iPSCs as a resource forendangered avian species conservation.

    DOI PubMed

  • Immortalization of common marmoset-derived fibroblasts via expression of cell cycle regulators using the piggyBac transposon

    Orimoto A, Shinohara H, Eitsuka T, Nakagawa K, Sasaki E, Kiyono T, Fukuda T

    Tissue and Cell ( Elsevier )  77   101848   2022.08  [Refereed]

    Bulletin of University, Institute, etc.  Multiple authorship

    DOI PubMed

  • SIG-1451, a non-steroidal anti-inflammatory drug, attenuates light-induced photoreceptor degeneration by inhibiting micro-glial activation.

    Kikuchi Y, Sugano E, Yuki S, Tabata K, Endo Y, Takita Y, Onoguchi R, Ozaki T, Fukuda T, Takai Y, Kurose T, Takanaka K, Honma Y, Perez E, Stock M, Fermandez J, Tamura M, WVoronkov M, Stock J, Tomita H

    International Journal of Molecular Science   15   8802   2022.08  [Refereed]

    Bulletin of University, Institute, etc.  Single Work

    PubMed

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Books 【 display / non-display 】

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Review Papers 【 display / non-display 】

  • Japanese golden eagle conservation science: current status and future needs

    Rob OGDEN, Tomokazu FUKUDA, Takayuki FUNO, Mamoru KOMATSU, Taku MAEDA, Anna MEREDITH, Masaya MIURA, Haruki NATSUKAWA, Manabu ONUMA, Yuki OSAFUNE, Keisuke SAITO, Yu SATO, Des THOMPSON, Miho INOUE-MURAYAMA

    Japanese Journal of Zoo Wildlife Medicine ( Japanese Society of Zoo Wildlife Medicine )  25 ( 1 ) 9 - 28   2020.03

    Academic Journal  

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Presentations 【 display / non-display 】

  • Comparison of BLV infectivity between bovine leukemia virus susceptible and resistant cattle

    Oral Presentation(General)  Lanlan Bai, Liushiqi Borjigin, Hirotaka Sato, ShinNosuke Takeshima, Tomokazu Fukuda, Sakurako, Asaji, Asako Ando, Hidetoshi Inoko, Yoko Aida

    2022.09
    　
    　

  • Immortalized sheep muscle-derived cells with the expression of CDK4 R24C, cyclin D1, and telomerase reverse transcriptase

    Oral Presentation(General) 

    2022.05
    　
    　

  • Primary and immortalized cell lines derived from the Amami rabbit (Pentalagus furnessi) and evolutionally conserved cell cycle control with CDK4 and Cyclin D1

    Poster (General)  Masafumi Katayama 1, Ai Orimoto 2, Tetsuya Tani 3, Keiko Ito 4, Takahiro Eitsuka 5, Kiyotaka Nakagawa 5, Miho Inoue-Murayama 6, Manabu Onuma 1, Tohru Kiyono 7,*, and Tomokazu Fukuda 2,*

    The 14th Asian Society of Conservation Medicine/ 27th Japanese Society of Zoo and wildlife Medicine 2021 Joint Conference Front line of One Health in Asia  (Sappro) 

    2021.09
    　
    　

    The 14th Asian Society of Conservation Medicine

  • Establishment of muscle derived fibroblasts and immortalized cells from Common minke whale (Balaenoptera acutorostrata)

    Poster (General)  Aya Sekine 1, Izzah Munirah 1, Genta Yasunaga 2, Eriko Sugano 1, Hiroshi Tomita 1, Miho Inoue- Murayama 3, Tohru Kiyono 4,*, Tomokazu Fukuda 1,*

    The 14th Asian Society of Conservation Medicine/ 27th Japanese Society of Zoo and wildlife Medicine 2021 Joint Conference Front line of One Health in Asia  (Sappro) 

    2021.09
    　
    　

    The 14th Asian Society of Conservation Medicine

  • RNA-seq analysis a,omg multiple pig derived induced pluripotent stem cell line.

    Poster (General)  Donai K, Kobayashi H, Hirano T, Fukuda T.

    2017.09
    　
    　

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Academic Awards Received 【 display / non-display 】

  • English Presentation Award

    2019.09.20

    All winners： Tomokazu Fukuda

  • 2017.03.30

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