Affiliation |
IWATE University Faculty of Science and Engineering Department of Chemistry and Biological Science Studies in Biological Sciences |
Position |
Professor |
Tomokazu Fukuda
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Research Interests 【 display / non-display 】
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Immortalized Cell
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Critically Endangered Species
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Radioactive Safety Evaluation
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Carcinogenesis
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Livestock Science
Graduating School 【 display / non-display 】
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-1999.03
Kobe University Faculty of Agriculture Graduated
Graduate School 【 display / non-display 】
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-1999.03
Nara Medical University Graduate School, Division of Medicine Doctor's Course Completed
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-1993.03
Kobe University Graduate School, Division of National Science and Technology Master's Course Completed
Degree 【 display / non-display 】
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Nara Medical University - Ph.D. 1999.03.31
Campus Career 【 display / non-display 】
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2017.05-Now
IWATE University Faculty of Agriculture Food Animal Medicine & Food Safety Research Center Professor [Concurrently]
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2016.04-Now
IWATE University Faculty of Agriculture Veterinary Medicine Professor [Concurrently]
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2016.04-Now
IWATE University Faculty of Science and Engineering Department of Chemistry and Biological Science Studies in Biological Sciences Professor [Duty]
External Career 【 display / non-display 】
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2008.04-2016.03
Tohoku University Associate Professor
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2005.05-2008.03
National Cancer Center Research Institute of Japan Technical Support Staff
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2001.02-2005.04
National Institute of Environmental Health Sciences, NIEHS-NIH Visiting Fellow
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1999.04-2001.01
Japanese Foundation of Cancer Research Technical Support Staff
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1993.04-1995.03
生物環境科学研究所 Staff Scientist
Research Areas 【 display / non-display 】
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Life Science / Animal production science
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Life Science / Pathological biochemistry
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Environmental Science/Agriculture Science / Conservation of biological resources
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Environmental Science/Agriculture Science / Radiation influence
Recommended URL 【 display / non-display 】
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Laboratory of Cell Engineering and Molecular Genetics
Course Subject 【 display / non-display 】
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2020
Probability and Statistics
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2020
Human Anatomy
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2020
Biological Science and Engineering Laboratory 2
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2020
Biological Science and Engineering Laboratory 1
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2020
Reading Academic Papers in English 1
Published Papers 【 display / non-display 】
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Properties of a Single Amino Acid Residue in the Third Transmembrane Domain Determine the Kinetics of Ambient Light-Sensitive Channelrhodopsin
Hatakeyama A, Sugano E, Sayama T, Watanabe Y, Suzuki T, Tabata K, Endo Y, Sakajiri T, Fukuda T, Ozaki T, Tomita H
International Journal of Molecular Science 24 ( 5 ) 5054 2023.03 [Refereed]
Bulletin of University, Institute, etc. Single Work
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Matsusaka H, Wu T, Furuya K, Yamada-Kato T, Bai L, Tomita H, Sugano E, Ozaki T, Kiyono T, Okunishi I, Fukuda T
Scientific Data ( Nature Springer ) 9 731 2022.11 [Refereed]
Bulletin of University, Institute, etc. Multiple authorship
Testosterone-related steroid hormones are associated with various types of diseases, including prostate cancer and androgenetic alopecia (AGA). The testosterone or dihydroxy testosterone (DHT) circulates through the blood, binds to the androgen receptor (AR) in the cytoplasm, and finally enters the nucleus to activate downstream target genes. We previously found that immortalized dermal papilla cells (DPCs) lost AR expression, which may be explained by the repeated cell passages of DPCs. To compensate for the AR expression, DPCs that express AR exogenously were established. In this study, we performed an RNA-Seq analysis of the AR-expressing and non-AR-expressing DPCs in the presence or absence of DHT to identify the downstream target genes regulated by AR signalling. Furthermore, we treated DPCs with minoxidil sulphate, which has the potential to treat AGA. This is the first comprehensive analysis to identify the downstream genes involved in testosterone signalling in DPCs. Our manuscript provides high-priority data for the discovery of molecular targets for prostate cancer and AGA.
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Induced pluripotent stem cells of endangered avian species
Katayama M, Fukuda T, Kaneko T, Nakagawa Y, Tajima A, Naito M, Ohmaki H, Endo D, Asano M, Nagamine T, Nakaya Y, Saito K, Watanabe Y, Tani T, Inoue-Murayama M, Nakajima N, Onuma M
Communications biology ( Nature Publishing ) 5 1049 - 1059 2022.10 [Refereed]
Bulletin of University, Institute, etc. Multiple authorship
The number of endangered avian-related species increase in Japan recently. The applicationof new technologies, such as induced pluripotent stem cells (iPSCs), may contribute to therecovery of the decreasing numbers of endangered animals and conservation of geneticresources. We established novel iPSCs from three endangered avian species (Okinawa rail,Japanese ptarmigan, and Blakiston’sfish owl) with seven reprogramming factors (M3O,Sox2,Klf4,c-Myc,Nanog,Lin28, andKlf2). The iPSCs are pluripotency markers and expresspluripotency-related genes and differentiated into three germ layers in vivo and in vitro.These three endangered avian iPSCs displayed different cellular characteristics even thoughthe same reprogramming factors use. Japanese ptarmigan-derived iPSCs have differentbiological characteristics from those observed in other avian-derived iPSCs. Japanese ptar-migan iPSCs contributed to chimeras part in chicken embryos. To the best of our knowledge,ourfindings provide thefirst evidence of the potential value of iPSCs as a resource forendangered avian species conservation.
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Immortalization of common marmoset-derived fibroblasts via expression of cell cycle regulators using the piggyBac transposon
Orimoto A, Shinohara H, Eitsuka T, Nakagawa K, Sasaki E, Kiyono T, Fukuda T
Tissue and Cell ( Elsevier ) 77 101848 2022.08 [Refereed]
Bulletin of University, Institute, etc. Multiple authorship
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SIG-1451, a non-steroidal anti-inflammatory drug, attenuates light-induced photoreceptor degeneration by inhibiting micro-glial activation.
Kikuchi Y, Sugano E, Yuki S, Tabata K, Endo Y, Takita Y, Onoguchi R, Ozaki T, Fukuda T, Takai Y, Kurose T, Takanaka K, Honma Y, Perez E, Stock M, Fermandez J, Tamura M, WVoronkov M, Stock J, Tomita H
International Journal of Molecular Science 15 8802 2022.08 [Refereed]
Bulletin of University, Institute, etc. Single Work
Books 【 display / non-display 】
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Masafumi Katayama, Tomokazu Fukuda ( Pages responsible : CHAPTER 8 Establishment of induced pluripotent stem cells from prairie vole-derived fibroblast )
Academic Press 2020.10 ISBN: I012822228X
Scholarly Book
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Yasuyuki Abe, Hideaki Yamashiro, Yasushi Kino, Toshinori Oikawa, Masatoshi Suzuki, Yusuke Urushihara, Yoshikazu Kuwahara, Motoko Morimoto, Jin Kobayashi, Tsutomu Sekine, Tomokazu Fukuda, Emiko Isogai, and Manabu Fukumoto
Springer 2020.01
Scholarly Book
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Banri Suzuki, Shigefumi Tanaka, Kohichi Nishikawa, Chikako Yoshida, Takahisa Yamada, Yasuyuki Abe, Tomokazu Fukuda, Jin Kobayashi, Gohei Hayashi, Masatoshi Suzuki, Yusuke Urushihara, Kazuma Koarai, Yasushi Kino, Tsutomu Sekine, Atsushi Takahasi, Toshihiro Shimizu, Hisashi Shinoda, Kazuki Saito, Emiko Isogai, Koh Kawasumi, Satoshi Sugimura, Hideaki Yamashiro, and Manabu Fukumoto
Springer 2020.01
Scholarly Book
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Kazuma Koarai, Yasushi Kino, Toshitaka Oka, Atsushi Takahashi, Toshihiko Suzuki, Yoshinaka Shimizu, Mirei Chiba, Ken Osaka, Keiichi Sasaki, Yusuke Urushihara, Tomokazu Fukuda, Emiko Isogai, Hideaki Yamashiro, Manabu Fukumoto, Tsutomu Sekine, and Hisashi Shinoda
Springer 2020.01
Scholarly Book
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Tomokazu Fukuda
Springer 2020.01
Scholarly Book
Review Papers 【 display / non-display 】
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Japanese golden eagle conservation science: current status and future needs
Rob OGDEN, Tomokazu FUKUDA, Takayuki FUNO, Mamoru KOMATSU, Taku MAEDA, Anna MEREDITH, Masaya MIURA, Haruki NATSUKAWA, Manabu ONUMA, Yuki OSAFUNE, Keisuke SAITO, Yu SATO, Des THOMPSON, Miho INOUE-MURAYAMA
Japanese Journal of Zoo Wildlife Medicine ( Japanese Society of Zoo Wildlife Medicine ) 25 ( 1 ) 9 - 28 2020.03
Academic Journal
Presentations 【 display / non-display 】
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Comparison of BLV infectivity between bovine leukemia virus susceptible and resistant cattle
Oral Presentation(General) Lanlan Bai, Liushiqi Borjigin, Hirotaka Sato, ShinNosuke Takeshima, Tomokazu Fukuda, Sakurako, Asaji, Asako Ando, Hidetoshi Inoko, Yoko Aida
2022.09 -
Immortalized sheep muscle-derived cells with the expression of CDK4 R24C, cyclin D1, and telomerase reverse transcriptase
Oral Presentation(General)
2022.05 -
Primary and immortalized cell lines derived from the Amami rabbit (Pentalagus furnessi) and evolutionally conserved cell cycle control with CDK4 and Cyclin D1
Poster (General) Masafumi Katayama 1, Ai Orimoto 2, Tetsuya Tani 3, Keiko Ito 4, Takahiro Eitsuka 5, Kiyotaka Nakagawa 5, Miho Inoue-Murayama 6, Manabu Onuma 1, Tohru Kiyono 7,*, and Tomokazu Fukuda 2,*
The 14th Asian Society of Conservation Medicine/ 27th Japanese Society of Zoo and wildlife Medicine 2021 Joint Conference Front line of One Health in Asia (Sappro)
2021.09The 14th Asian Society of Conservation Medicine
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Establishment of muscle derived fibroblasts and immortalized cells from Common minke whale (Balaenoptera acutorostrata)
Poster (General) Aya Sekine 1, Izzah Munirah 1, Genta Yasunaga 2, Eriko Sugano 1, Hiroshi Tomita 1, Miho Inoue- Murayama 3, Tohru Kiyono 4,*, Tomokazu Fukuda 1,*
The 14th Asian Society of Conservation Medicine/ 27th Japanese Society of Zoo and wildlife Medicine 2021 Joint Conference Front line of One Health in Asia (Sappro)
2021.09The 14th Asian Society of Conservation Medicine
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RNA-seq analysis a,omg multiple pig derived induced pluripotent stem cell line.
Poster (General) Donai K, Kobayashi H, Hirano T, Fukuda T.
2017.09
Academic Awards Received 【 display / non-display 】
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English Presentation Award
2019.09.20
All winners: Tomokazu Fukuda
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2017.03.30