Published Papers - ONODA Toshiyuki
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Rapid weight change as a predictor of disability among community-dwelling Japanese older adults
Megumi Tsubota-Utsugi, Kozo Tanno, Naomi Takahashi, Toshiyuki Onoda, et,al.
geriatrics & gerontology international ( 日本老年医学会 ) 23 ( 11 ) 809 - 816 2023.09 [Refereed]
Academic Journal Multiple authorship
We analyzed data from a longitudinal study of 10 375 community-dwelling older Japanese adults (≥65 years) who were not LTCI needs certified at baseline and joined the study from 2002 to 2005. Weight change (percentage) was calculated by subtracting participants' weight in the previous year from that measured during a physical examination at study commencement. The five weight-change categories ranged from sizable weight loss (≤ -8.0%) to sizable weight gain (≥ +8.0%). Disability was defined according to LTCI certifications at follow-up. Hazard ratios (HRs) and 95% confidence intervals were calculated for new-onset disability using a Cox proportional hazards model that fitted the proportional subdistribution hazards regression model with weights for competing risks of death.
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The Potential of a Stroke Registry Using Diagnosis Procedure Combination Data from All Hospitals in a Japanese Prefecture
Shinichi Omama , Kozo Tanno , Yoshihiro Inoue , Kuniaki Ogasawara , Takeshi Fukuda , Yuetsu Oikawa , Toshiyuki Onoda , Masaki Ohsawa , Kiyomi Sakata
Cerebrovascular diseases ( KARGER INTERNATIONAL ) 51 ( 4 ) 447 - 452 2022.01 [Refereed]
Academic Journal Multiple authorship
Of the 71 hospitals with 9,992 beds in the Iwate Prefecture in 2018, 50 hospitals with 8,316 beds participated in the DPC system. The proportion of registered cases from participating hospitals was 95.2% (44,779/47,018) for all stroke types (95.6% men and 94.9% women), 94.3% for cerebral infarction, 97.0% for intracerebral hemorrhage, and 98.7% for subarachnoid hemorrhage. Attending doctors and researchers registered 486 and 41 CVD cases from the core and noncore hospitals, respectively, whereas 455 and 46 CVD cases were extracted from the DPC data of these hospitals, respectively. This yielded 86.6% sensitivity, 99.3% specificity, 92.5% positive predictive value, and 98.7% negative predictive value for the core hospital; these values were 92.7%, 98.6%, 82.6%, and 99.5%, respectively, for the noncore hospital.
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Association between Milk Intake and Incident Stroke among Japanese Community Dwellers: The Iwate-KENCO Study.
Tanno K. , Yonekura Y, Okuda N , Kuribayashi T , Yabe E, Tsubota M, Omama S , Onoda T , et al.
Nutrients 13 ( 11 ) 3781 2021.10 [Refereed]
Academic Journal Multiple authorship
We aimed to evaluate the association between the milk consumption and incident stroke in a Japanese population, where milk consumption is lower than that of Western countries. In total, 14,121 participants (4253 men and 9868 women) aged 40–69 years, free from cardiovascular diseases(CVD) were prospectively followed for 10.7 years. Participants were categorized into four groups according to the milk intake frequency obtained from a brief-type self-administered diet questionnaire.
The adjusted HRs of total stroke, ischemic stroke and haemorrhagic stroke associated with milk intake frequency were calculated using the Cox proportional hazards model. During the follow-up, 478 stroke cases were detected (208 men and 270 women). Compared to women with a milk intake of <2 cups/week, those with an intake of 7 to <12 cups/week had a significantly low risk of ischemic stroke in a model adjusting CVD risk factors; the HR (95% CI) was 0.53 (0.32–0.88). No significant associations were found in men. This study suggested that milk intake of 7 to <12 cups/week
decreased the risk of ischemic stroke in Japanese women. Milk intake of about 1 to <2 cups/day may
be effective in the primary prevention of ischemic stroke in a population with low milk intake. -
Slightly Elevated Serum Ionic Fluoride Levels Inhibit Insulin Secretion and Increase Glucose Levels in a General Japanese Population: a Cross-sectional Study
Itai K , Onoda T , Nohara M , Kuribayashi T , Tanno K , Ohsawa M , Mori M , Okayama A
Biological Trace Element Research 199 ( 8 ) 2819 - 2825 2021.08
Academic Journal Multiple authorship
A cross-sectional study was performed to investigate the relationships between serum fluoride levels, glucose levels, and insulin secretion in a general population. A total of 330 healthy subjects (167 men; 163 women) aged between 40 and 69 years were examined. Lifestyle information was obtained using questionnaires. Blood samples were collected in the early morning, and biochemical parameters and glucose indices were measured. Serum ionic fluoride (SIF) levels were assessed using a highly sensitive method. Relationships between glucose indices and SIF levels were investigated using a multiple linear regression analysis. SIF levels positively correlated with fasting plasma glucose (FPG) and glycohemoglobin (HbA1c) levels in both sexes. In women, SIF levels negatively correlated with homeostasis model assessment insulin secretion (HOMA-β) levels. In men, the proportion of regular drinkers negatively correlated with HOMA-β, but not SIF levels. Although SIF levels < 1 μmol/L were associated with reduced insulin secretion and increased FPG levels, the risk of diabetes was not elevated. These results suggest that increased SIF levels caused by a large fluoride intake and compromised renal function combined with poor lifestyle choices elevate the risk of diabetes. Further studies are warranted to elucidate the effects of fluoride on glucose metabolism.
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Occurrence of Cerebrovascular Diseases Decreased after the Great East Japan Earthquake and Tsunami of 2011
Omama S, Yoshida Y, Ogasawara K, Ogawa A, Ishibashi Y, Nakamura M, Tanno K, Ohsawa M, Onoda T, Itai K, Sakata K.
Cerebrovascular diseases extra ( S. Karger AG ) 10 ( 3 ) 105 - 115 2020.10
Academic Journal Multiple authorship
The occurrence of CVDs in the flooded coastal areas did not increase in the year of the Great East Japan Earthquake and Tsunami; furthermore, it decreased for men according to the severity of flood damage in the subsequent years; this can be attributed to supportive activities for the tsunami victims and the migration of the population.
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Ten-Year Cerebrovascular Disease Trend Occurrence by Population-based Stroke Registry in an Aging Japan Local Prefecture
Shinichi Omama , Kuniaki Ogasawara , Yoshihiro Inoue , Yasuhiro Ishibashi , Masaki Ohsawa , Toshiyuki Onoda , Kazuyoshi Itai , Kozo Tanno , Kiyomi Sakata
journal of stroke and cerebrovascular diseases ( National stroke association ) 29 ( 3 ) 2020.03 [Refereed]
International Conference Proceedings Multiple authorship
The cerebrovascular diseases rate and number of incidence decreased during the last decade and will decrease in the future, but the incidence in the oldest-old will increase. Specific nursing care and social measures to treat cerebrovascular diseases in the oldest-old will be needed.
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一般集団における非高血圧者の心電図上左室肥大所見は心血管疾患のリスクである
田中健太郎, 田中文隆, 小野田敏行, 丹野高三, 大澤正樹, 坂田清美, 大間々真一, 小笠原邦昭, 石橋靖宏, 板井一好, 栗林徹, 岡山明, 中村元行, Iwate-Kenco Study Group
American journal of hypertension 31 ( 8 ) 895 - 901 2018.07 [Refereed]
Academic Journal Multiple authorship
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日本の糖尿病患者集団の脳卒中発症への高血圧の寄与について
古味良亮、田中文隆、大間々真一、石橋靖宏、丹野高三、小野田敏行、大澤正樹、田中健太郎、岡山明、中村元行
Hypertension Research 41 531 - 538 2018.04 [Refereed]
Academic Journal Multiple authorship
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一般集団におけるＢＮＰ検査の心原性脳梗塞の予測性について
中村元行、石橋靖宏、田中文隆、大間々真一、小野田敏行、高橋智弘、高橋宗康、丹野高三、大澤正樹、坂田清美、腰山誠、小笠原邦昭、岡山明
Circulation Journal 82 ( 4 ) 1017 - 1025 2018.04 [Refereed]
International Conference Proceedings Multiple authorship
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2006年から2014年の日本の農村地域における急性心筋梗塞発症および臨床的特徴の推移について
中村元行、田中文隆、瀬川利恵、高橋智弘、松浦佑樹、酒井敏彰、新山正展、小野田敏行、腰山誠
Circulation Journal 81 ( 12 ) 1854 - 1861 2017.12 [Refereed]
International Conference Proceedings Multiple authorship
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2011年の日本での大地震および津波が心筋梗塞の発症に及ぼす長期的な影響について
中村元行、田中賢太郎、田中文隆、松浦佑樹、新山正展、肥田頼彦、酒井敏彰、小野田敏行、伊藤智範
The American Journal of Cardiology 120 352 - 358 2017.05 [Refereed]
Academic Journal Multiple authorship