論文 - 西山 賢一
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CdsA is involved in biosynthesis of glycolipid MPIase essential for membrane protein integration in vivo
Sawasato, K., Sato, R., Nishikawa, H., Iimura, N., Kamemoto, Y., Fujikawa, K., Yamaguchi, T., Kuruma, Y., Tamura, Y., Endo, T., Ueda, T., Shimamoto, K., Nishiyama, K.
Sci. Rep. 9 No1372 2019年02月 [査読有り]
国際的学術誌 共著・分担
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Syntheses and activities of the functional structures of a glycolipid essential for membrane protein integration
Fujikawa, K., Suzuki, S., Nagase, R., Ikeda, S., Mori, S., Nomura, K., Nishiyama, K., Shimamoto, K.
ACS Chem. Biol. 13 2719 - 2727 2018年10月 [査読有り]
国際的学術誌 共著・分担
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Structural basis of Sec-independent membrane protein insertion by YidC
Kumazaki, K., Chiba, S., Takemoto, M., Furukawa, A., Nishiyama, K., Sugano, Y., Mori, T., Dohmae, N., Hirata, K., Nakada-Nakura, Y. Maturana, A.D., Tanaka, Y., Mori, H., Sugita, Y., Arisaka, F., Ito, K., Ishitani, R., Tsukazaki, T. and Nureki, O.
Nature 509 516 - 520 2014年05月 [査読有り]
学術誌 共著・分担
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Glycolipozyme MPIase is essential for topology inversion of SecG during preprotein translocation
Moser M., Nagamori, S., Huber, M., Tokuda, H., Nishiyama, K.
Proc. Natl. Acad. Sci. USA 110 ( 24 ) 9734 - 9739 2013年06月 [査読有り]
国際的学術誌 共著・分担
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MPIase is a glycolipozyme essential for membrane protein integration
Ken-ichi Nishiyama, Masahide Maeda, Kayo Yanagisawa, Ryohei Nagase, Hajime Komura, Takashi Iwashita, Tohru Yamagaki, Shoichi Kusumoto, Hajime Tokuda & Keiko Shimamoto
Nature Communications 3 ( 1260 ) 1 - 10 2012年12月 [査読有り]
学術誌 共著・分担
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大腸菌膜タンパク質の膜挿入に関与する酵素様糖脂質MPIase
藤川 紘樹、西山 賢一、島本 啓子
Trends in Glycoscience and Glycotechnology 2019年08月 [査読有り]
学術誌 共著・分担
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Enzyme-like glycolipids MPIase involved in membrane protein integration of E. coli
Kohki Fujikawa, Ken-ichi Nishiyama and Keiko Shimamoto
Trends in Glycoscience and Glycotechnology 2019年08月 [査読有り]
国際的学術誌 共著・分担
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Biosynthesis of glycolipid MPIase (membrane protein integrase) is independent of the genes for ECA (enterobacterial common antigen)
Kamemoto, Y., Funaba, N., Kawakami, M., Sawasato, K., Kanno, K., Suzuki, S., Nishikawa, H., Sato, S., and Nishiyama, K.
J. Gen. Appl. Microbiol. 66 169 - 174 2020年07月 [査読有り]
国際的学術誌 共著・分担
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Two-step induction of cdsA promoters leads to upregulation of the glycolipid MPIase at cold temperature
Sawasato K, Sekiya Y, Nishiyama K.
FEBS Lett. 2019年06月 [査読有り]
国際的学術誌 共著・分担
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Alteration of membrane physicochemical properties by two factors for membrane protein integration.
Nomura K, Yamaguchi T, Mori S, Fujikawa K, Nishiyama KI, Shimanouchi T, Tanimoto Y, Morigaki K, Shimamoto K.
Biophys. J. 116 1 - 12 2019年06月 [査読有り]
国際的学術誌 共著・分担
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Expression of alcohol oxidase gene from Ochrobactrum sp. AIU 033 in recombinant Escherichia coli through the twin-arginine translocation pathway
Matsumura, K., Yamada, M., Yamashita, T., Muto, H., Nishiyama, K., Shimoi, S. and Isobe, K.
J. Biosci. Bioeng. 128 13 - 21 2019年06月 [査読有り]
国際的学術誌 共著・分担
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Increased expression of the bacterial glycolipid MPIase is required for efficient protein translocation across membranes in cold conditions
Sawasato, K., Suzuki, S., and Nishiyama, K.
J. Biol. Chem. 294 8403 - 8411 2019年05月 [査読有り]
国際的学術誌 共著・分担
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YnbB is a CdsA paralogue dedicated to biosynthesis of glycolipid MPIase involved in membrane protein integration
Sato, R., Sawasato, K. and Nishiyama, K.
Biochem. Biophys. Res. Commun. 510 636 - 642 2019年02月 [査読有り]
国際的学術誌 共著・分担
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Molecular dynamics study of binary POPC bilayers: molecular condensing effects on membrane structure and dynamics
Hiroaki Saito, Tetsuya Morishita, Taku Mizukami, Ken-ichi Nishiyama, Kazutomo Kawaguchi, and Hidemi Nagao
J. Physics 1136 12022 2018年01月 [査読有り]
国際的学術誌 共著・分担
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Cholesterol blocks spontaneous insertion of membrane proteins into liposomes of phosphatidylcholine
Nakamura, S., Suzuki, S., Saito, H., Nishiyama, K.
J. Biochem. 163 313 - 319 2018年04月 [査読有り]
国際的学術誌 共著・分担
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Membrane insertion of F0 c subunit of F0F1 ATPase depends on glycolipozyme MPIase and is stimulated by YidC
Nishikawa, H., Sasaki, M., Nishiyama, K.
Biochem. Biophys. Res. Commun. 487 477 - 482 2017年05月 [査読有り]
国際的学術誌 共著・分担
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Novel translocation intermediate allows re-evaluation of roles of ATP, proton motive force and SecG at the late stage of preprotein translocation
Nishiyama, K. and Tokuda, H.
Gene. Cells 21 1353 - 1364 2016年12月 [査読有り]
学術誌 共著・分担
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Relationship between glycolipozyme MPIase and components comprising the protein transport machinery
Endo, Y. and Nishiyama, K.
Med. Res. Arch. 2 ( 11 ) 1 - 24 2015年12月 [査読有り]
学術誌 共著・分担
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Glycolipozyme membrane protein integrase (MPIase): recent data
Nishiyama, K. and Shimamoto, K.
BioMol Concepts 5 429 - 438 2014年11月 [査読有り]
国際的学術誌 共著・分担
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タンパク質膜挿入の鍵を握るグライコリポザイム～タンパク質でない酵素？～
島本啓子、西山賢一
実験医学増刊「代謝」 32 115 - 122 2014年09月 [査読有り]
学術誌 共著・分担
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膜タンパク質膜挿入の鍵を握る糖脂質酵素MPIase
島本啓子、西山賢一
生命化学研究レター 44 9 - 14 2014年02月
学会誌 共著・分担
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Multiple SecA molecules drive protein translocation across a single translocon with SecG inversion
Morita K, Tokuda H, Nishiyama K.
J. Biol. Chem. 287 ( 1 ) 455 - 464 2011年11月 [査読有り]
学術誌 共著・分担
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Preparation of a highly translocation-competent proOmpA/SecB complex
Nishiyama K, Tokuda H
Protein Science 19 2402 - 2408 2010年12月 [査読有り]
学術誌 共著・分担
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A novel complete reconstitution system for membrane integration of the simplest membrane protein
Nishiyama K, et al
Biochem Biophys Res Commun 394 733 - 736 2010年04月 [査読有り]
学術誌 共著・分担
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Development of a functional in vitro integration system for an integral membrane protein, SecG
Nishiyama K, Tokuda H
Biochem Biophys Res Commun 390 920 - 924 2009年12月 [査読有り]
学術誌 共著・分担
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Diacylglycerol specifically blocks spontaneous integration of membrane proteins and allows detection of a factor-assisted integration
Kawashima Y, Miyazaki E, Müller M, Tokuda H, Nishiyama K
J Biol Chem 283 24489 - 244896 2008年09月 [査読有り]
学術誌 共著・分担
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The periplasmic chaperone PpiD interacts with secretory proteins exiting from the SecYEG translocon
Antonoaea R, Fürst M, Nishiyama K, Müller M
Biochemistry 47 5649 - 5656 2008年05月 [査読有り]
学術誌 共著・分担
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Topology inversion of SecG is essential for cytosolic SecA-dependent stimulation of protein translocation
Sugai R, Takemae K, Tokuda H, Nishiyama K
J Biol Chem 2007年10月 [査読有り]
学術誌 共著・分担
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A derivative of lipid A is involved in signal recognition particle/SecYEG-dependent and -independent membrane integrations
Nishiyama K, Ikegami A, Moser M, Schiltz E, Tokuda H, Müller M
J Biol Chem 281 35667 - 35676 2006年11月 [査読有り]
学術誌 共著・分担
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Disruption of rpmJ encoding ribosomal protein L36 decreases the expression of secY upstream of the spc operon and inhibits protein translocation in Escherichia coli
Ikegami A, Nishiyama K, Matsuyama S, Tokuda H
Biosci Biotechnol Biochem 69 1595 - 1602 2005年08月 [査読有り]
学術誌 共著・分担
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Genes coding for SecG and Leu2-tRNA form an operon to give an unusual RNA comprising mRNA and a tRNA precursor
Nishiyama K, Tokuda H
Biochim Biophys Acta 1729 166 - 173 2005年07月 [査読有り]
学術誌 共著・分担
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Development of a minimal cell-free translation system for the synthesis of presecretory and integral membrane proteins
Kuruma Y, Nishiyama K, Shimizu Y, Müller M, Ueda T
Biotechnol Prog 21 1243 - 1251 2005年07月 [査読有り]
学術誌 共著・分担
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Overexpression of gnsA, a multicopy suppressor of the secG null mutation, increases acidic phospholipid contents by inhibiting phosphatidylethanolamine synthesis at low temperatures
Sugai R, Shimizu H, Nishiyama K, Tokuda H
J Bacteriol 186 5968 - 5971 2004年09月 [査読有り]
学術誌 共著・分担
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Depletion of SecDF-YajC causes a decrease in the level of SecG: implication for their functional interaction
Kato Y, Nishiyama K, Tokuda H
FEBS Lett 550 114 - 118 2003年08月 [査読有り]
学術誌 共著・分担
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Membrane topology inversion of SecG detected by labeling with a membrane-impermeable sulfhydryl reagent that causes a close association of SecG with SecA
Nagamori S, Nishiyama K, Tokuda H
J Biochem 132 629 - 634 2002年10月 [査読有り]
学術誌 共著・分担
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Overexpression of yccL (gnsA) and ydfY (gnsB) increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation of Escherichia coli
Sugai R, Shimizu H, Nishiyama K, Tokuda H
J Bacteriol 183 5523 - 5528 2001年10月 [査読有り]
学術誌 共著・分担
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Role of the non-essential region encompassing the N-terminal two transmembrane stretches of Escherichia coli SecE
Nishiyama K, Suzuki H, Tokuda H
Biosci Biotechnol Biochem 64 2121 - 2127 2000年10月 [査読有り]
学術誌 共著・分担
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Two SecG molecules present in a single protein translocation machinery are functional even after crosslinking
Nagamori S, Nishiyama K, Tokuda H
J Biochem 128 129 - 137 2000年07月 [査読有り]
学術誌 共著・分担
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Increases in acidic phospholipid contents specifically restore protein translocation in a cold-sensitive secA or secG null mutant
Suzuki H, Nishiyama K, Tokuda H
J Biol Chem 274 31020 - 31024 1999年10月 [査読有り]
学術誌 共著・分担
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Membrane deinsertion of SecA underlying proton motive force-dependent stimulation of protein translocation
Nishiyama K, Fukuda A, Morita K, Tokuda H
EMBO J 18 1049 - 1058 1999年02月 [査読有り]
学術誌 共著・分担
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Molecular cloning and functional characterization of SecE of a marine bacterium, Vibrio alginolyticus
Nishiyama K, Furuta M, Tokuda H
Biochem Biophys Res Commun 251 894 - 897 1998年10月 [査読有り]
学術誌 共著・分担
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Coupled structure changes of SecA and SecG revealed by the synthetic lethality of the secAcsR11 and delta secG::kan double mutant
Suzuki H, Nishiyama K, Tokuda H
Mol Microbiol 29 331 - 341 1998年07月 [査読有り]
学術誌 共著・分担
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Expression of gpsA encoding biosynthetic sn-glycerol 3-phosphate dehydrogenase suppresses both the LB- phenotype of a secB null mutant and the cold-sensitive phenotype of a secG null mutant
Shimizu H, Nishiyama K, Tokuda H
Mol Microbiol 26 1013 - 1021 1997年12月 [査読有り]
学術誌 共著・分担
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Roles of the conserved cytoplasmic region and non-conserved carboxy-terminal region of SecE in Escherichia coli protein translocase
Kontinen VP, Yamanaka M, Nishiyama K, Tokuda H
J Biochem 119 1124 - 1130 1996年06月 [査読有り]
学術誌 共著・分担
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SecG plays a critical role in protein translocation in the absence of the proton motive force as well as at low temperature
Hanada M, Nishiyama K, Tokuda H
FEBS Lett 381 25 - 28 1996年02月 [査読有り]
学術誌 共著・分担
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Preferential interaction of Sec-G with Sec-E stabilizes an unstable Sec-E derivative in the Escherichia coli cytoplasmic membrane
Nishiyama K, Mizushima S, Tokuda H
Biochem Biophys Res Commun 217 217 - 223 1995年12月 [査読有り]
学術誌 共著・分担
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Reconstitution of an efficient protein translocation machinery comprising SecA and the three membrane proteins, SecY, SecE, and SecG (p12)
Hanada M, Nishiyama KI, Mizushima S, Tokuda H
J Biol Chem 269 23625 - 23631 1994年09月 [査読有り]
学術誌 共著・分担
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Band 1 subunit of Escherichia coli preportein translocase and integral membrane export factor P12 are the same protein
Douville K et al
J Biol Chem 269 18705 - 18707 1994年07月 [査読有り]
学術誌 共著・分担
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Disruption of the gene encoding p12 (SecG) reveals the direct involvement and important function of SecG in the protein translocation of Escherichia coli at low temperature
Nishiyama K, Hanada M, Tokuda H
EMBO J 13 3272 - 3277 1994年07月 [査読有り]
学術誌 共著・分担
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A novel membrane protein involved in protein translocation across the cytoplasmic membrane of Escherichia coli
Nishiyama K, Mizushima S, Tokuda H
EMBO J 12 3409 - 3415 1993年09月 [査読有り]
学術誌 共著・分担
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Effect of a rare leucine codon, TTA, on expression of a foreign gene in Streptomyces lividans
Ueda Y, Taguchi S, Nishiyama K, Kumagai I, Miura K
Biochim Biophys Acta 1172 262 - 266 1993年03月 [査読有り]
学術誌 共著・分担
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The carboxyl-terminal region of SecE interacts with SecY and is functional in the reconstitution of protein translocation activity in Escherichia coli
Nishiyama K, Mizushima S, Tokuda H
J Biol Chem 267 7170 - 7176 1992年04月 [査読有り]
学術誌 共著・分担
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SecN, a novel factor comprising the protein translocation machinery of Escherichia coli
Nishiyama K., Mizushima S. Tokuda H
J Cell Biochem 16 17 - 17 1992年02月 [査読有り]
その他（含・紀要） 共著・分担
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SecY is an indispensable component of the protein secretory machinery of Escherichia coli
Nishiyama K, Kabuyama Y, Akimaru J, Matsuyama S, Tokuda H, Mizushima S
Biochim Biophys Acta 1065 89 - 97 1991年05月 [査読有り]
学術誌 共著・分担
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Relationship between utilization of dual translational initiation signals and protein processing in Streptomyces
Taguchi S, Nishiyama K, Kumagai I, Momose H, Miura K
Mol Gen Genet 226 328 - 331 1991年04月 [査読有り]
学術誌 共著・分担
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Purification of SecE and reconstitution of SecE-dependent protein translocation activity
Tokuda H, Akimaru J, Matsuyama S, Nishiyama K, Mizushima S
FEBS Lett 279 233 - 236 1991年02月 [査読有り]
学術誌 共著・分担
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Analysis of transcriptional control regions in the Streptomyces subtilisin-inhibitor-encoding gene
Taguchi S, Nishiyama K, Kumagai I, Miura K
Gene 84 279 - 286 1989年12月 [査読有り]
学術誌 共著・分担
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MucA is a small peptide encoded by an overlapping sequence with cdsA that upregulates the biosynthesis of glycolipid MPIase in the cold
Runa Hikage, Yuta Tadika, Haruka Asanuma, Youjung Han, Ken-Ichi Nishiyama
Biochem Biophys Res Commun 721 150148 2024年05月 [査読有り]
国際的学術誌 共著・分担
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CdsA, a CDP-diacylglycerol synthase involved in phospholipid and glycolipid MPIase biosynthesis, possesses multiple initiation codons
Runa Hikage, Yusei Sekiya, Katsuhiro Sawasato, Ken-ichi Nishiyama
Genes toGenes 29 347 - 355 2024年02月 [査読有り]
国際的学術誌 共著・分担
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Coordinated upregulation of two CDP-diacylglycerol synthases, YnbB and CdsA, is essential for cell growth and membrane protein export in the cold
Yuki Kamemoto, Runa Hikage, Youjung Han, Yusei Sekiya, Katsuhiro Sawasato, Ken-ichi Nishiyama
FEMS Microbiology Letters 370 fnad131 2023年12月 [査読有り]
国際的学術誌 共著・分担
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Structural requirements of a glycolipid MPIase for membrane protein integration
Kohki Fujikawa, Youjung Han, Tsukiho Osawa, Shoko Mori, Kaoru Nomura, Maki Muramoto, Ken-Ichi Nishiyama, Keiko Shimamoto
Chem. Eur. J. 2023年03月 [査読有り]
国際的学術誌 共著・分担
-
A bacterial glycolipid essential for membrane protein integration
Fujikawa, K., Mori, S., Nishiyama, K., Shimamoto, K.
Adv. Carbohydr. Chem. Biochem. 81 95 - 129 2022年11月 [査読有り]
国際的学術誌 共著・分担
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Interaction between glycolipid MPIase and proteinaceous factors during protein integration into the cytoplasmic membrane of E. coli
Nishikawa, H., Sawasato, K., Mori, S., Fujikawa, K., Nomura, K., Shimamoto,K., and Nishiyama, K.
Front. Mol. Biosci. 9 986602 2022年08月 [査読有り]
国際的学術誌 共著・分担
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Role of a bacterial glycolipid in Sec-independent membrane protein insertion
Nomura, K., Mori, S., Fujikawa, K., Osawa, T., Tsuda, S., Yoshizawa-Kumagaye, K., Masuda, S., Nishio, H., Yoshiya, T., Yoda, T., Shionyu, M., Shirai, T., Nishiyama, K., Shimamoto, K
Sci. Rep. 12 12231 2022年07月 [査読有り]
国際的学術誌 共著・分担
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Intermolecular interactions between a membrane protein and a glycolipid essential for membrane protein integration
Shoko Mori, Kaoru Nomura, Kohki Fujikawa, Tsukiho Osawa, Masafumi Shionyu, Takao Yoda, Tsuyoshi Shirai, Shugo Tsuda, Kumiko Yoshizawa-Kumagaye, Shun Masuda, Hideki Nishio, Taku Yoshiya, Sonomi Suzuki, Maki Muramoto, Ken-ichi Nishiyama, and Keiko Shimamoto
ACS Chem Biol 17 ( 3 ) 609 - 618 2022年03月
国際的学術誌 共著・分担
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Interplay between MPIase, YidC, and PMF during Sec-independent insertion of membrane proteins
Yuta Endo, Yuko Shimizu, Hanako Nishikawa, Katsuhiro Sawasato, Ken-ichi Nishiyama
Life Sci Alliance 5 e202101162 - e202101162 2021年10月 [査読有り]
国際的学術誌 共著・分担
-
Yusei Sekiya, Katsuhiro Sawasato, Ken‐ichi Nishiyama
Genes Cells 26 727 - 738 2021年06月 [査読有り]
国際的学術誌 共著・分担
-
大腸菌におけるタンパク質膜輸送に関与する糖脂質MPIase の発現制御機構～酵素様機能をもつ糖脂質MPIase～
沢里克宏, 藤川紘樹, 島本啓子, 西山賢一
化学と生物 58 223 - 230 2021年04月 [査読有り]
学術誌 共著・分担
-
Ring assembly of c subunits of F0F1-ATP synthase in Propionigenium modestum requires YidC and UncI following MPIase-dependent membrane insertion
Hanako Nishikawa, Kotoka Kanno, Yuta Endo, Ken-ichi Nishiyama
FEBS Lett 595 647 - 654 2021年01月 [査読有り]
学術誌 共著・分担
-
In vitro assay for bacterial membrane protein integration into proteoliposomes
Nishikawa Hanako、Sasaki Masaru、Nishiyama Ken-ichi
Bio Protocol 10 e3626 2020年05月 [査読有り]
国際的学術誌 共著・分担
-
大腸菌におけるタンパク質膜輸送に関与する糖脂質MPIase の発現制御機構～酵素様機能をもつ糖脂質
沢里克宏, 藤川紘樹, 島本啓子, 西山賢一
化学と生物 58 2020年03月 [査読有り]
学術誌 共著・分担
-
The bacterial protein YidC accelerates MPIase-dependent integration of membrane proteins
Sasaki, M., Nishikawa, H., Suzuki, S., Moser, M., Huber, M., Sawasato, K., Matsubayashi, H., Kumazaki, K., Tsukazaki, T., Kuruma, Y., Nureki, O., Ueda, T., Nishiyama, K
J. Biol. Chem. 294 18898 - 18908 2019年12月 [査読有り]
国際的学術誌 共著・分担
-
Free energy profiles of lipid translocation across pure POPC and POPC/CHOL bilayer: all-atom molecular dynamics study
Saito, H., Morishita, T., Mizukami, T., Nishiyama, K., Kawaguchi, K., Nagao, H.
J. Physics 2019年11月 [査読有り]
国際的学術誌 共著・分担
-
Novel Glycolipid Involved in Membrane Protein Integration: Structure and Mode of Action
Fujikawa Kohki、Nomura Kaoru、Nishiyama Ken-ichi、Shimamoto Keiko
Journal of Synthetic Organic Chemistry, Japan 77 1096 - 1105 2019年11月 [査読有り]
国際的学術誌 共著・分担
-
Inversion of the membrane topology of SecG coupled with SecA-dependent preprotein translocation
Nishiyama K, Suzuki T, Tokuda H
Cell 85 71 - 81 1996年04月 [査読有り]
学術誌 共著・分担